Aggression can ensue due to exposure to an intimidating situation.Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gamma-aminobutyric acid, dopamine and their receptor subtypes.The present study investigated the ability of 100, 200 and 400 mg/kg of ethanolic extract of Capparis zeylanica Asian Soup Spoons root (EECZ) circumvent aggression.
Foot shock induced aggression, isolation-induced aggression, resident-intruder aggression and water competition test were utilized as models for screening of antiaggressive activity.Extract was given orally at three different dose levels (100, 200 and 400 mg/kg) once daily for three consecutive days, while Diazepam (2.5 mg/kg), was administered as positive control.
EECZ significantly (p<0.05) minimized aggression dose dependently in the entire Sunglasses dose (100, 200, 400 mg/kg).Results suggested that EECZ showed significant antiagressive activity in aforementioned validated models of aggression.
EECZ at all dose levels (100, 200 and 400 mg/kg) have shown promising anti-aggressive activity qualitatively comparable to that of diazepam (2.5 mg/kg).